Fowler determined dead space volume using Bohr’s formula, with the conclusion that the regional non-uniformity of ventilation and lung volume were the most important factors in determining the dead space volume. Klocke acknowledged that dead space values were important in the past, because alveolar ventilation was calculated from total ventilation using an assumed or empirical value for dead space. Bohr used a mass balance method to measure dead space through the information of tidal volume, mixed alveolar gas, and expired alveolar gas compositions. The problem concerning the nature and the function of dead space is of basic importance for the full comprehension of the respiratory physiology and pathophysiology. See more Open Access OptionĮxtended studies on the concept of dead space have been made in the last half-century. Measurement devices (pressure, temperature, flow, voltage, frequency etc.), precision engineering, medical devices, instrumentation for education (devices and software), sensor technology, mechatronics and robotics. Solid-state physics, radio engineering, telecommunications, control systems, signal processing, power electronics, electronic devices and circuits and automation. Operations research, systems engineering, management science, complex systems and cybernetics applications and information technologies Electronic Engineering Computer ScienceĬomputer graphics and visualization, programming, human-computer interaction, neural networks, image processing and software engineering. JART classifies research into the following main fields: Material Scienceīiomaterials, carbon, ceramics, composite, metals, polymers, thin films, functional materials and semiconductors. The journal does not charge for submission, processing, publication of manuscripts or for color reproduction of photographs. JART publishes manuscripts describing original research, with significant results based on experimental, theoretical and numerical work.

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Derivation of physiologic dead space